Not all obesity is the same: explore rare melanocortin-4 receptor (MC4R) pathway diseases
Acquired hypothalamic obesity
Learn more about acquired hypothalamic obesity, a disease characterized by accelerated and sustained weight gain that occurs most frequently after hypothalamic injury, and its unique pathophysiology involving impaired MC4R pathway signaling leading to dysregulated energy balance.
Rare MC4R pathway diseases: mechanism of disease video
Learn more about the MC4R pathway and the role of rare genetic variants in MC4R pathway signaling.
MC4R pathway-associated obesities
Learn about the melanocortin-4 receptor (MC4R) pathway that regulates energy balance, the clinical characteristics of several rare genetic diseases, and when to consider genetic testing.
Bardet-Biedl syndrome (BBS)
Learn about the clinical features, prevalence, pathophysiology, and diagnosis of Bardet-Biedl syndrome, a rare genetic disease.
BBS: educational video
Learn more about how to diagnose BBS.
Understanding and identifying Bardet-Biedl syndrome (BBS)
Bardet-Biedl syndrome (BBS)
Learn about the clinical features, prevalence, pathophysiology, and diagnosis of Bardet-Biedl syndrome, a rare genetic disease.
BBS: educational video
Learn more about how to diagnose BBS.
Not all hunger is the same: understanding and identifying hyperphagia
Hyperphagia questionnaire
Learn how to identify hyperphagia in your patients with rare MC4R pathway diseases, and to determine if/how it is impacting their daily lives.
Rhythm Pharmaceuticals: who we are
About Rhythm Pharmaceuticals
Learn about Rhythm’s dedication to pioneering research and development of treatments for rare MC4R pathway diseases and our clinical development pipeline.
Genetic testing: uncovering obesity-associated gene variants
Frequency of Obesity-Associated Gene Variants From Uncovering Rare Obesity® Genetic Testing Program
Learn about the frequency of obesity-associated gene variants uncovered in Rhythm’s Uncovering Rare Obesity® testing program
Uncovering Rare Obesity®
Learn about Uncovering Rare Obesity® program, a genetic testing program that helps identify rare genetic diseases of obesity. https://uncoveringrareobesity.com
Discover more
Expand your knowledge of rare genetic variants and their role in MC4R pathway signaling.
BBS, Bardet-Biedl syndrome; LEPR, leptin receptor gene; MC4R, melanocortin-4 receptor; NCOA1, nuclear receptor coactivator 1 gene (also referred to as SRC1); POMC, proopiomelanocortin gene; PCSK1, proprotein convertase subtilisin/kexin type 1 gene
