Not all obesity is the same: explore rare melanocortin-4 receptor (MC4R) pathway diseases
Rare MC4R pathway diseases: mechanism of disease video
Learn more about the MC4R pathway and the role of rare genetic variants in MC4R pathway signaling.
MC4R pathway-associated obesities
Learn about the melanocortin-4 receptor (MC4R) pathway that regulates energy balance, the clinical characteristics of several rare genetic diseases, and when to consider genetic testing.
Bardet-Biedl syndrome (BBS)
Learn about the clinical features, prevalence, pathophysiology, and diagnosis of Bardet-Biedl syndrome, a rare genetic disease.
BBS: educational video
Learn more about how to diagnose BBS.
Understanding and identifying Bardet-Biedl syndrome (BBS)
Bardet-Biedl syndrome (BBS)
Learn about the clinical features, prevalence, pathophysiology, and diagnosis of Bardet-Biedl syndrome, a rare genetic disease.
BBS: educational video
Learn more about how to diagnose BBS.
Not all hunger is the same: understanding and identifying hyperphagia
Hyperphagia questionnaire
Learn how to identify hyperphagia in your patients with rare MC4R pathway diseases, and to determine if/how it is impacting their daily lives.
Rhythm Pharmaceuticals: who we are
About Rhythm Pharmaceuticals
Learn about Rhythm’s dedication to pioneering research and development of treatments for rare MC4R pathway diseases and our clinical development pipeline.
Genetic testing: uncovering obesity-associated gene variants
Frequency of Obesity-Associated Gene Variants From Uncovering Rare Obesity® Genetic Testing Program
Learn about the frequency of obesity-associated gene variants uncovered in Rhythm’s Uncovering Rare Obesity® testing program
Uncovering Rare Obesity®
Learn about Uncovering Rare Obesity® program, a genetic testing program that helps identify rare genetic diseases of obesity. https://uncoveringrareobesity.com
Ongoing clinical trials
Rhythm’s Clinical Development Program
Acquired Hypothalamic Obesity: Phase 3 Trial Design
Learn about hypothalamic obesity and our ongoing phase 3 clinical trial in patients with acquired hypothalamic obesity.
To learn more, visit: https://clinicaltrials.gov/study/NCT05774756
About the EMANATE Clinical Trial
Learn about our phase 3 trial, EMANATE, in patients with obesity and POMC, PCSK1, and LEPR heterozygous variants, or variants in NCOA1 or SH2B1.
To learn more, visit: https://clinicaltrials.gov/study/NCT05093634
Discover more
Expand your knowledge of rare genetic variants and their role in MC4R pathway signaling.
BBS, Bardet-Biedl syndrome; LEPR, leptin receptor gene; MC4R, melanocortin-4 receptor; NCOA1, nuclear receptor coactivator 1 gene (also referred to as SRC1); POMC, proopiomelanocortin gene; PCSK1, proprotein convertase subtilisin/kexin type 1 gene
